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I. Kev Siv Tshuaj Antimicrobial Dav Dav Uas Tsis Sib Xws

5-Chloro-2-methyl-4-isothiazolin-3-ib (CMIT), nrog rau cov mis molecular C₄H₄ClNOS thiab qhov hnyav molecular ntawm 149.6, sawv cev rau ib qho ntawm cov isothiazolinone compounds uas tau lees paub thiab ntseeg siab tshaj plaws hauv kev lag luam khaws cia thoob ntiaj teb. Muaj qhov ntsuas Book Index ntawm 10—qhov ntsuas kev nyab xeeb thiab kev ntseeg siab tshaj plaws—CMITtau tsim nws tus kheej ua lub hauv paus ntawm kev tiv thaiv kab mob niaj hnub no thoob plaws ntau yam kev siv hauv kev lag luam.

Chiv thawj tsim thiab lag luam los ntawm Rohm thiab Haas nyob rau hauv lub npe nrov Kathon ™, CMIT feem ntau yog siv ua ib qho tseem ceeb ntawm kev sib xyaw ua ke 3: 1 nrog Methylisothiazolinone (MIT). Qhov kev sib xyaw ua ke muaj zog no suav tias yog ib qho ntawm cov tshuaj tua kab mob dav dav uas pheej yig tshaj plaws thiab ua haujlwm tau zoo tshaj plaws hauv kev lag luam thoob ntiaj teb. CMIT tau ua kev zoo siab rau nws qhov kev ua haujlwm dav dav, ua kom tsis txhob muaj kev loj hlob ntawm cov kab mob (ob qho tib si Gram-positive thiab negative), fungi, poov xab, thiab algae. Lub tshuab tom qab nws lub zog nyob hauv nws cov bioactive sulfur moiety, uas oxidizes thiol-muaj cov seem hauv cov hlwb microbial, cuam tshuam lawv cov protein thiab enzymes thiab thaum kawg ua rau cov hlwb tuag sai. Qhov kev tshuaj tiv thaiv electrophilic no tsom mus rau cov txheej txheem metabolic tseem ceeb, xyuas kom meej tias cov kab mob me me tsis tuaj yeem tsim kev tiv thaiv sai - qhov zoo dua li ntau lwm cov tshuaj tiv thaiv. Ntawm qhov concentration qis li 150 ppm, nws tuaj yeem tiv thaiv cov kab mob loj hlob tag nrho, thiab ntawm 125 ppm, nws tag nrho inhibits poov xab thiab pwm, xyuas kom meej cov khoom ruaj khov thiab kev nyab xeeb thaum lub sijhawm khaws cia thiab siv.

II. Kev Siv Ntau Yam Hauv Kev Lag Luam Thoob Plaws Cov Chaw Tseem Ceeb

Qhov siv tau ntawm5-Chloro-2-methyl-4-isothiazolin-3-ibnthuav dav thoob plaws ntau yam kev lag luam, muab kev txuag tseem ceeb hauv cov chaw nyuaj uas muaj kev sib kis kab mob ua rau muaj kev pheej hmoo loj rau cov khoom zoo thiab kev nyab xeeb ua haujlwm.

Hauv kev kho dej hauv kev lag luam, CMIT siv dav hauv kev ncig dej txias, kev kho dej khib nyiab, thiab cov txheej txheem dej kom tswj tau cov kab mob me me thiab tiv thaiv kev ua kom tsis muaj zog. Cov biofilms tuaj yeem txo qhov ua haujlwm hloov pauv cua sov thiab ua kom cov kav dej thiab cov khoom siv xeb sai dua. Los ntawm kev tshem tawm cov zej zog microbial no, CMIT ua kom muaj kev ua haujlwm zoo thiab lub neej ntev ntawm cov khoom siv hauv kev lag luam nyuaj, txo cov nqi kho thiab lub sijhawm tsis ua haujlwm. Hauv kev lag luam coatings,CMITyog ib qho tseem ceeb rau kev khaws cia hauv lub thawv, tiv thaiv cov xim pleev xim, cov emulsions, thiab cov nplaum los ntawm cov kab mob me me thaum lub sijhawm khaws cia. Yog tsis muaj kev khaws cia txaus, cov khoom no yuav yooj yim rau cov kab mob thiab cov kab mob fungal loj hlob uas ua rau muaj ntxhiab tsw, hloov pauv viscosity, thiab thaum kawg cov khoom tsis ua haujlwm. Cov roj thiab roj av vam khom CMIT los tawm tsam cov kab mob me me hauv cov kua dej drilling thiab cov tshuab roj. Cov kab mob sulfate-txo tuaj yeem tsim cov hydrogen sulfide, ua rau cov pas dej tsis zoo thiab cov khoom siv hlau xeb heev. Tsis tas li ntawd,CMITua haujlwm ua ib qho tshuaj tiv thaiv zoo hauv cov tshuaj ntxuav tais diav, xab npum ntxuav tais diav, thiab lwm yam tshuaj ntxuav hauv tsev, tiv thaiv kev loj hlob ntawm cov kab mob me me uas yuav ua rau cov khoom puas tsuaj.

III. Lub Luag Haujlwm Tseem Ceeb hauv Kev Saib Xyuas Tus Kheej nrog Kev Txwv Tsis Pub Dhau

ThaumCMITyog ib qho tshuaj tua kab mob zoo heev, nws daim ntawv thov hauv kev saib xyuas tus kheej yog raug kev tswj hwm nruj vim nws paub tias muaj peev xwm ua rau muaj kev tsis haum tshuaj. Hauv kev lag luam tshuaj pleev ib ce, nws feem ntau siv rau hauv cov khoom ntxuav tawm xws li tshuaj zawv plaub hau, tshuaj pleev, thiab tshuaj ntxuav lub cev, qhov twg nws cov kev ua haujlwm tiv thaiv muaj zog pab tswj cov khoom kom zoo. Txawm li cas los xij, daim ntawv thov no xav tau kev ua tib zoo, vim CMIT yog ib qho tshuaj ua rau muaj kev tsis haum tshuaj uas tuaj yeem ua rau muaj kev tsis haum tshuaj rau cov neeg uas muaj kev phom sij.

Raws li Cosmetic Safety Technical Specification (2015 Edition), qhov sib tov 3:1 ntawm CMIT/MIT tsuas yog tso cai rau hauv cov khoom siv pleev kom huv si uas muaj qhov siab tshaj plaws ntawm 0.0015% (15 ppm). Qhov kev siv qis heev no qhia txog lub zog zoo kawg nkaus ntawm cov tshuaj - txawm tias muaj qhov tsawg kawg nkaus, nws muab kev tiv thaiv txaus tiv thaiv ntau yam kab mob. Tshaj qhov kev txwv no ua rau muaj kev pheej hmoo loj rau kev noj qab haus huv, suav nrog daim tawv nqaij liab, khaus, pob khaus, thiab kev ua xua hnyav. Cov kev ua tsis ntev los no hauv ntau thaj chaw hais txog qhov tseem ceeb ntawm kev ua raws li cov lus qhia kev nyab xeeb no. Cov chaw tsim khoom yuav tsum tswj hwm cov txheej txheem tswj hwm zoo, cov txheej txheem dosing meej, thiab kev sim cov khoom xyaw kom huv si kom ntseeg tau tias muaj kev nyab xeeb ntawm cov neeg siv khoom thaum siv nws lub zog tshwj xeeb.

IV. Kev Ruaj Ntseg, Kev Sib Xws, thiab Cov Txiaj Ntsig ntawm Kev Tsim Qauv

Ntxiv rau nws cov kev ua haujlwm tiv thaiv kab mob muaj zog,CMITmuaj qhov zoo tseem ceeb los ntawm kev tsim cov qauv. CMIT qhia tau tias muaj kev ruaj khov zoo heev thoob plaws ntau yam pH, feem ntau tswj nws cov txiaj ntsig ntawm pH 2 thiab 9, ua rau nws haum rau ntau yam khoom lag luam los ntawm cov qauv ntxuav acidic rau cov emulsions tsis muaj zog thiab cov kua dej alkaline me me. Nws qhov kev ruaj khov thermal ua kom ntseeg tau tias nws tseem ua haujlwm txawm tias nyob rau hauv cov chaw ua haujlwm uas muaj qhov kub siab.

CMITkuj qhia txog kev sib raug zoo nrog cov khoom xyaw feem ntau siv, suav nrog nonionic, anionic, thiab amphoteric surfactants, nrog rau ntau yam polymers, thickeners, thiab emulsifiers. Qhov kev sib raug zoo no txo ​​qhov kev pheej hmoo ntawm kev sib cuam tshuam tsis zoo uas yuav ua rau kev tsis ruaj khov ntawm cov qauv lossis txo cov txiaj ntsig zoo ntawm cov tshuaj tiv thaiv. Tsis zoo li qee cov tshuaj tiv thaiv ib txwm muaj uas yuav teb nrog lwm cov khoom los tsim cov precipitates, CMIT sib xyaw ua ke seamlessly rau hauv cov qauv tsis muaj kev cuam tshuam cov khoom zoo nkauj xws li xim, tsw, lossis kev ntxhib los mos. Ntxiv mus, CMIT tsis pab txhawb rau formaldehyde tso tawm lossis muaj cov kuab tshuaj halogenated, ua rau nws yog qhov kev xaiv zoo dua rau ib puag ncig piv rau qee cov thev naus laus zis tiv thaiv qub.

 V. Lub Luag Haujlwm Tseem Ceeb ntawm CMIT hauv Cov Txheej Txheem Tiv Thaiv Niaj Hnub Nim No

Txawm hais tias muaj kev txwv tsis pub siv nws,CMITtseem yog ib qho cuab yeej tseem ceeb hauv cov khoom siv tsim khoom. Nws qhov kev siv nyiaj tsis sib xws - ua tiav kev khaws cia zoo ntawm qhov tsawg heev - ua rau nws pheej yig dua li ntau lwm cov tshuaj preservatives uas xav tau cov koob tshuaj ntau dua. Nws qhov kev tua sai sai muab kev tiv thaiv tam sim ntawd tiv thaiv cov xwm txheej kev ua qias tuaj, uas yog qhov tseem ceeb tshwj xeeb hauv cov chaw tsim khoom uas cov khoom lag luam tsis muaj zog thaum lub sijhawm tsim khoom thiab ntim khoom. Nws cov haujlwm dav dav ua kom muaj kev tiv thaiv tag nrho tawm tsam ntau yam kab mob me me uas feem ntau hem cov khoom lag luam, ua rau cov tswv yim khaws cia yooj yim.

Saib rau pem hauv ntej,CMIT covLub luag haujlwm hauv kev txuag kev lag luam yuav tsum txuas ntxiv mus, tshwj xeeb tshaj yog nyob rau hauv cov ntawv thov uas tsis yog cov khoom siv pleev xim uas nws cov kev ua tau zoo tshaj plaws thiab cov txiaj ntsig zoo tseem tsis tau sib piv. Kev tshawb fawb txuas ntxiv mus rau hauv cov thev naus laus zis tshiab thiab cov txheej txheem xa khoom tiv thaiv yuav txhim kho nws cov qauv kev nyab xeeb, ua rau nws siv tau txuas ntxiv thaum daws cov teeb meem kev noj qab haus huv thiab ib puag ncig. Raws li kev lag luam txuag hloov pauv mus rau cov kev daws teeb meem ruaj khov dua, CMIT yuav tswj hwm nws txoj haujlwm ua tus neeg sawv cev tiv thaiv kab mob tseem ceeb - ib qho uas sib npaug ntawm kev ua tau zoo nrog kev cog lus tob rau kev nyab xeeb thiab kev lav phib xaub.