Polycaprolactone CAS 24980-41-4

I. 3D Printing Field: Cov khoom siv zoo tshaj plaws rau kev ua haujlwm siab thiab kev hloov kho kom haum

Hauv kev lag luam ntawm 3D luam ntawv (kev tsim khoom ntxiv), polycaprolactone PCL tau dhau los ua ib qho ntawm cov ntaub ntawv luam ntawv 3D uas tuaj yeem lwj tau vim nws qhov melting point qis (kwv yees li 60 ℃), yaj fluidity zoo thiab interlayer bonding zog. PCL polymer yog qhov tshwj xeeb tshaj yog rau cov kev siv tshuab xws li fused Deposition modeling (FDM) thiab stereolithography, thiab siv dav hauv cov xwm txheej hauv qab no:

Tus qauv tus kheej thiab prototype ua:Polycaprolactone PCL muaj qhov kub nruab nrab uas ua rau nws tsis yooj yim tawg lossis tawg thaum lub sijhawm luam ntawv. Nws tuaj yeem ua raws li cov qauv nyuaj (xws li cov qauv tshuab thiab cov qauv me me), thiab cov khoom luam tawm muaj qhov du thiab zoo, tsis tas yuav ua tiav ntau dhau. Lub caij no, cov khoom lwj ntawm Polycaprolactone PCL ua rau nws tsim nyog rau "ib zaug siv" cov qauv (xws li cov qauv sim khoom siv hauv tsheb), txo cov khoom pov tseg.

Kev luam ntawv 3D Biomedical Ua ib yam khoom siv uas muaj kev sib raug zoo zoo heev:polycaprolactone PCL sawv tawm hauv kev luam ntawv ntawm cov ntaub so ntswg engineering scaffolds. Los ntawm kev kho qhov hnyav molecular ntawm cov khoom siv lossis sib xyaw nrog cov tshuaj bioactive xws li hydroxyapatite (HA) thiab collagen, porous scaffolds uas phim cov kev xav tau kev loj hlob ntawm cov ntaub so ntswg xws li pob txha thiab pob txha mos tuaj yeem npaj tau. Lub scaffold tuaj yeem maj mam lwj hauv lub cev, muab qhov chaw txhawb nqa rau cov ntaub so ntswg tshiab. Tam sim no, PCL polymer tau siv rau hauv kev tshawb fawb luam ntawv kho mob xws li kev kho pob txha thiab kev rov ua dua tshiab ntawm daim tawv nqaij.

Hauv kev kawm thiab kev muaj tswv yim:Qhov kub qis ntawm polycaprolactone PCL ua rau kev luam ntawv tsis tas yuav siv cov khoom siv kub siab, ua kom muaj kev nyab xeeb siab. Nws yog qhov tsim nyog ua cov khoom siv qhia rau 3D luam ntawv hauv cov xwm txheej kev kawm. polycaprolactone PCL yog siv los tsim cov qauv qhia (xws li cov qauv ntawm tib neeg lub cev thiab cov qauv tshuaj molecular). Lub caij no, nws tus yam ntxwv ntawm kev hloov pauv maj mam ntawm chav tsev kub kuj txhawb nqa qhov chaw tsim qauv muaj tswv yim hauv kev ua cov duab kos duab lossis cov khoom ua si nrog cov duab hloov kho tau.

II. Kev Ntim Khoom Noj Khoom Haus Pov Tseg: Ob qho kev lav phib xaub ntawm kev puas tsuaj ntsuab thiab kev tiv thaiv kev nyab xeeb

Hauv kev lag luam ntim khoom noj pov tseg, polycaprolactone PCL tau dhau los ua lwm txoj hauv kev tseem ceeb rau cov yas uas tsis lwj (xws li polyethylene thiab polypropylene) vim nws muaj peev xwm lwj tag nrho, muaj cov yam ntxwv zoo thiab muaj kev nyab xeeb rau kev sib cuag nrog zaub mov, pab daws qhov teeb meem ntawm "kev ua qias tuaj dawb". Nws cov ntawv thov tseem ceeb suav nrog

Zaj duab xis/hnab ntim khoom noj uas lwj tau:PCL tuaj yeem sib xyaw thiab hloov kho nrog cov khoom siv polymer ntuj xws li hmoov txhuv nplej siab thiab polylactic acid (PLA) los txhim kho qhov yooj ywm thiab dej tsis kam ntawm cov ntaub ntawv, thiab ua rau hauv cov yeeb yaj kiab lossis cov hnab khaws cia rau kev ntim khoom noj tshiab (xws li txiv hmab txiv ntoo thiab zaub) thiab cov khoom noj siav - hom ntim no tuaj yeem siv rau hauv cov chaw ib puag ncig ntuj (xws li av thiab cov av composting) polycaprolactone PCL tuaj yeem maj mam lwj mus rau hauv carbon dioxide thiab dej hauv 6 txog 12 lub hlis yam tsis muaj kev ua qias tuaj. Lub caij no, PCL polymer muaj kev ruaj khov tshuaj zoo heev thiab tsis cuam tshuam nrog roj lossis cov tshuaj acidic hauv cov khoom noj, ua tau raws li cov qauv kev nyab xeeb rau cov khoom siv sib cuag zaub mov (xws li FDA daim ntawv pov thawj).

Cov thawv ntim khoom noj thiab cov khoom siv hauv rooj tog uas siv ib zaug xwb:Los ntawm kev txhaj tshuaj molding lossis cov txheej txheem kub nias, polycaprolactone PCL tuaj yeem sib xyaw nrog cov nroj tsuag fibers (xws li straw fibers, xyoob fibers) los tsim cov thawv noj su pov tseg, phaj, riam, rab diav rawg thiab lwm yam khoom. Hom khoom no tsis yog tsuas yog muaj peev xwm thauj khoom zoo heev thiab tiv taus cua sov (muaj peev xwm tiv taus cov zaub mov kub ntawm 60-80 ℃), tab sis PCL polymer kuj tseem tuaj yeem lwj los ntawm kev ua composting tom qab siv, zam kev ua qias tuaj rau ib puag ncig mus sij hawm ntev los ntawm cov tais diav yas ib txwm muaj. Nws yog qhov tshwj xeeb tshaj yog rau cov xwm txheej ntim khoom pov tseg ntau zaus xws li kev noj mov thiab zaub mov ceev ceev.

Iii. Cov Ntaub Ntawv Kho Mob: Cov ntaub ntawv tseem ceeb rau kev sib raug zoo ntawm cov tsiaj txhu thiab kev hloov pauv ua haujlwm

Hauv kev ua cov phaj kho mob, polycaprolactone (PCL) tau dhau los ua cov khoom siv tseem ceeb rau kev tsim cov phaj kho mob thiab cov phaj tiv thaiv vim nws muaj kev nyab xeeb zoo heev, kev puas tsuaj tswj tau thiab cov khoom siv kho tshuab. Nws cov lus qhia tseem ceeb suav nrog:

Cov laug cam kho mob:Hauv cov teb xws li orthopedics thiab kev kho hniav, polycaprolactone PCL tuaj yeem txhim kho nws lub zog kho tshuab los ntawm kev hloov kho (xws li kev sib xyaw hydroxyapatite thiab tricalcium phosphate), thiab ua rau cov pob txha kho qhov tsis zoo thiab cov pob txha alveolar reconstruction boards. Tom qab raug cog rau hauv tib neeg lub cev, hom pawg thawj coj no tsis tsuas yog muab kev txhawb nqa tam sim ntawd rau cov pob txha puas tsuaj tab sis kuj maj mam lwj nrog rau kev rov ua dua tshiab ntawm lub cev cov pob txha, zam kev pheej hmoo ntawm kev phais mob thib ob rau kev tshem tawm. Lub caij no, qhov biocompatibility ntawm polycaprolactone PCL tuaj yeem txo qhov kev tsis lees paub tom qab cog, txhawb kev sib txuas ntawm tes thiab kev sib koom ua ke ntawm cov ntaub so ntswg, thiab tau siv rau hauv kev phais kho pob txha tsawg kawg nkaus.

Cov laug cam tiv thaiv thiab cais tawm kev kho mob:PCL muaj cov khoom zoo heev uas ua rau zaj duab xis thiab thaiv tau zoo heev thiab tuaj yeem ua rau cov laug cam cais kev kho mob (xws li cov laug cam tiv thaiv phab ntsa rau chav phais thiab cov txheej cais qhov chaw rau cov khoom siv kho mob). Hom laug cam no tsis yog tsuas yog tiv thaiv kev nkag mus ntawm cov kab mob thiab cov kab mob xwb, tab sis kuj muaj qee qhov kev ywj pheej thiab kev tiv thaiv kev tua kab mob. Nws tuaj yeem tiv taus kev so ntau zaus nrog cawv thiab cov tshuaj tua kab mob uas muaj chlorine, thiab nws tuaj yeem lwj tom qab pov tseg, txo qhov siab ntawm kev kho cov khib nyiab kho mob. Tsis tas li ntawd, polycaprolactone PCL kuj tseem tuaj yeem ua ke nrog cov neeg sawv cev tua kab mob (xws li cov nyiaj ions) los txhim kho kev ua haujlwm tua kab mob ntev ntawm cov laug cam tiv thaiv, ua rau nws tsim nyog rau cov xwm txheej uas muaj kev xav tau siab heev rau kev huv huv ib puag ncig, xws li chav kho mob sib kis thiab chav kho mob ICUS.

Iv. Lwm Cov Teb: Cov teb txuas ntxiv ua haujlwm

Ntxiv rau cov cheeb tsam tseem ceeb uas tau hais los saum toj no, polycaprolactone PCL kuj tseem ua lub luag haujlwm hauv ntau qhov xwm txheej:

Cov txheej thiab cov nplaum:polycaprolactone PCL, ua ib feem tseem ceeb ntawm cov txheej txheem dej lossis cov kuab tshuaj, tuaj yeem txhim kho qhov yooj ywm, kev tiv thaiv kev cuam tshuam thiab kev tiv thaiv huab cua ntawm cov txheej - piv txwv li, thaum siv rau hauv txheej txheej sab nraud ntawm cov kav dej hlau, nws tuaj yeem txo qhov tawg ntawm cov txheej uas tshwm sim los ntawm kev sib cog lus ntawm cov kav dej vim qhov kub thiab txias hloov pauv. polycaprolactone PCL yog siv los ua txheej txheej rau cov khoom ua si yas, ua rau cov txheej txheej tiv taus kev hnav thiab tsis yooj yim tev tawm. Ntxiv mus, vim PCL nws tus kheej tsis muaj tshuaj lom, nws tuaj yeem ua tau raws li cov qauv kev nyab xeeb rau cov khoom ua si menyuam yaus. Tsis tas li ntawd, ntxiv PCL polymer rau cov txheej txheej ntoo kuj tseem tuaj yeem txhim kho cov xim ntawm cov ntoo thiab txhim kho cov qauv zoo nkauj.

Cov ntaub ntawv ua liaj ua teb:polycaprolactone PCL yog ua los ua cov zaj duab xis ua liaj ua teb uas lwj tau, uas siv rau kev cog qoob loo, khaws dej thiab chiv. Tom qab lwj tag, lawv tuaj yeem hloov mus ua cov organic hauv av, zam kev ua qias tuaj hauv av los ntawm cov zaj duab xis seem. Lossis nws tuaj yeem ua rau cov chiv qeeb qeeb kom tswj tau qhov tso tawm cov as-ham, thiab PCL polymer tuaj yeem txhim kho qhov siv chiv. Qhov "kev lwj tag uas tswj tau" ntawm PCL ua tau raws li qhov xav tau ntawm kev ua liaj ua teb rau "kev ua haujlwm" thiab "kev phooj ywg ib puag ncig", thiab feem ntau yog siv los daws cov teeb meem ua qias tuaj ntawm cov khoom siv ua liaj ua teb ib txwm muaj.

Cov khoom siv sib xyaw ua ke hloov kho:polycaprolactone PCL yog sib xyaw nrog polyolefins, polyester thiab lwm yam ntaub ntawv los txhim kho lawv qhov yooj ywm thiab lub zog cuam tshuam, ua rau nws haum rau cov xwm txheej uas muaj qhov xav tau siab rau kev ua tau zoo ntawm cov khoom siv, xws li cov khoom siv sab hauv tsheb thiab cov plhaub khoom siv hauv tsev.

Kev hloov kho fiber/npuag:polycaprolactone PCL yog siv rau kev txheej lossis kev hloov kho ntawm cov polyester thiab paj rwb fibers kom txhim kho lawv cov elasticity, hnav tsis kam thiab tiv thaiv kev laus. Piv txwv li, ntxiv PCL txheej rau cov ntaub kis las tuaj yeem ua rau cov ntaub ncab tau yooj yim dua thiab tsis yooj yim deformation. Grafting PCL rau hauv cov ntaub gauze kho mob tuaj yeem txhim kho kev nqus dej noo thiab khaws cia ntawm gauze, txhim kho nws cov nplaum rau ntawm daim tawv nqaij, thiab txo qhov tsis xis nyob los ntawm kev sib txhuam ntawm qhov txhab.