Hydroxypropyl beta-cyclodextrin muaj, tseem hu ua (2-hydroxypropyl) -β-cyclodextrin, yog hydrogen atom nyob rau hauv 2-, 3-, thiab 6-hydroxyl pawg ntawm cov piam thaj residues hauv β-cyclodextrin (β-CD) uas hloov los ntawm hydroxypropyl rau hydroxypropoxy. HP-β-CD tsis tsuas yog muaj lub hnab ntawv zoo heev rau ntau lub tebchaw xws li β-CD, tab sis kuj muaj qhov zoo ntawm cov dej solubility siab thiab txhim kho tus nqi tso tawm thiab bioavailability ntawm cov tshuaj encapsulated hauv vivo. Tsis tas li ntawd, HP-β-CD yog ib qho tshuaj excipient nrog cov ntaub ntawv kev nyab xeeb tshaj plaws uas tau sau tseg thiab tsis muaj kev phiv tshwm sim. HP-β-CD kuj tseem siv tau los ua cov protein tiv thaiv thiab stabilizer.
Hydroxypropyl beta-cyclodextrin yog dawb lossis dawb amorphous lossis crystalline hmoov; Tsis muaj ntxhiab, me ntsis qab zib; Muaj zog noo noo induction. Cov khoom no yooj yim soluble hauv dej, yooj yim soluble hauv methanol, ethanol, yuav luag insoluble hauv acetone, trichloromethane.
Solubility ntawmHydroxypropyl-B-Cyclodextrin yog cov khoom siv hauv tsevHauv dej yog qhov zoo heev, thiab qhov hloov pauv qib ntawm 4 thiab siab dua tuaj yeem ua rau miscible nrog dej hauv txhua qhov kev faib ua feem, thiab tseem tuaj yeem yaj hauv 50% ethanol thiab methanol. Nws muaj qee yam txheeb ze hygroscopicity. Tab sis qhov txheeb ze ntawm qhov chaw ua haujlwm thiab kev ua haujlwm hemolytic yog qhov tsawg. Nws tsis muaj qhov khaus rau cov leeg thiab yog cov kuab tshuaj zoo tshaj plaws thiab cov tshuaj excipient rau kev txhaj tshuaj.
Hydroxypropyl beta-cyclodextrin siv rau dab tsi?
Nyob rau hauv lub teb ntawm zaub mov thiab txuj lom
Hydroxypropyl beta-cyclodextrin tuaj yeem txhim kho kev ruaj ntseg thiab kev ua haujlwm ntev ntawm cov khoom noj khoom haus molecules, npog lossis kho cov ntxhiab tsw phem thiab saj ntawm cov khoom noj khoom haus molecules, thiab txhim kho cov txheej txheem tsim khoom thiab cov khoom zoo.
Hauv tshuaj pleev ib ce
Cov khoom siv raw ntawm cov tshuaj pleev ib ce tuaj yeem siv los ua stabilizers, emulsifiers, deodorizers, thiab lwm yam, uas tuaj yeem txo cov stimulation ntawm cov organic molecules hauv cov tshuaj pleev ib ce rau ntawm daim tawv nqaij thiab cov mucous daim nyias nyias, txhim khu kev ruaj ntseg ntawm cov khoom xyaw nquag, thiab tiv thaiv volatilization thiab oxidation ntawm cov as-ham. . Nws muaj qee yam txheeb ze hygroscopicity.
Hauv kev kho mob
Hydroxypropyl beta-cyclodextrin muajtuaj yeem txhim kho cov dej solubility ntawm cov tshuaj insoluble, ua kom cov tshuaj ruaj khov, txhim kho cov tshuaj bioavailability, nce kev ua tau zoo ntawm cov tshuaj npaj los yog txo qhov ntau npaum li cas, kho lossis tswj qhov tso tawm ceev ntawm cov tshuaj, thiab txo cov tshuaj toxicity. Nws tuaj yeem siv los ua cov khoom siv hauv qhov ncauj, txhaj tshuaj, cov tshuaj mucosal xa cov tshuab (xws li qhov ntswg mucosa, qhov quav, pob txha, thiab lwm yam), transdermal absorption drug delivery systems, lipophilic targeted drug, thiab tseem tuaj yeem siv los ua cov protein tiv thaiv thiab stabilizer.
Post lub sij hawm: Oct-20-2023