Hydroxypropyl beta-cyclodextrin, tseem hu ua (2-hydroxypropyl) -β-cyclodextrin, yog ib qho hydrogen atom hauv 2-, 3-, thiab 6-hydroxyl pawg ntawm cov glucose residues hauv β-cyclodextrin (β-CD) uas hloov los ntawm hydroxypropyl rau hydroxypropoxy. HP-β-CD tsis yog tsuas yog muaj cov nyhuv zoo heev rau ntau cov tshuaj xws li β-CD, tab sis kuj muaj qhov zoo ntawm kev yaj dej siab thiab txhim kho qhov kev tso tawm thiab bioavailability ntawm cov tshuaj encapsulated hauv vivo. Tsis tas li ntawd, HP-β-CD yog ib qho tshuaj excipient nrog cov ntaub ntawv kev nyab xeeb dav tshaj plaws thiab tsis muaj kev phiv tsis zoo. HP-β-CD kuj tseem siv tau ua tus tiv thaiv protein thiab stabilizer.
Hydroxypropyl beta-cyclodextrin yog dawb los yog dawb amorphous lossis crystalline hmoov; Tsis muaj ntxhiab, me ntsis qab zib; Muaj zog induction noo noo. Cov khoom no yog yooj yim soluble hauv dej, yooj yim soluble hauv methanol, ethanol, yuav luag insoluble hauv acetone, trichloromethane.
Qhov solubility ntawmhydroxypropyl-B-cyclodextrinHauv dej zoo heev, thiab qib hloov pauv ntawm 4 thiab siab dua tuaj yeem sib xyaw nrog dej hauv txhua qhov sib piv, thiab kuj tuaj yeem yaj hauv 50% ethanol thiab methanol. Nws muaj qee qhov hygroscopicity. Tab sis qhov ua haujlwm ntawm qhov chaw thiab kev ua haujlwm hemolytic yog qhov tsawg. Nws tsis muaj kev khaus rau cov leeg thiab yog qhov zoo tagnrho cov kuab tshuaj txhim kho thiab cov tshuaj ntxiv rau kev txhaj tshuaj.
Hydroxypropyl beta-cyclodextrin siv rau dab tsi?
Hauv kev lag luam khoom noj thiab tshuaj ntsuab
Hydroxypropyl beta-cyclodextrin tuaj yeem txhim kho qhov ruaj khov thiab kev ua haujlwm ntev ntawm cov khoom noj khoom haus, npog lossis kho cov ntxhiab tsw phem thiab saj ntawm cov khoom noj khoom haus, thiab txhim kho cov txheej txheem tsim khoom thiab cov khoom zoo.
Hauv cov tshuaj pleev ib ce
Cov khoom siv raw ntawm cov tshuaj pleev ib ce tuaj yeem siv ua cov stabilizers, emulsifiers, deodorizers, thiab lwm yam, uas tuaj yeem txo qhov kev txhawb nqa ntawm cov organic molecules hauv cov tshuaj pleev ib ce ntawm daim tawv nqaij thiab cov ntaub so ntswg mucous, txhim kho kev ruaj khov ntawm cov khoom xyaw nquag, thiab tiv thaiv kev volatilization thiab oxidation ntawm cov as-ham. Nws muaj qee qhov hygroscopicity.
Hauv kev kho mob
Hydroxypropyl beta-cyclodextrinNws tuaj yeem txhim kho qhov dej yaj ntawm cov tshuaj uas tsis yaj, ua kom cov tshuaj ruaj khov, txhim kho kev siv tshuaj, ua kom cov tshuaj ua haujlwm tau zoo dua lossis txo cov tshuaj ntau npaum li cas, kho lossis tswj qhov ceev ntawm kev tso tawm cov tshuaj, thiab txo cov tshuaj lom. Nws tuaj yeem siv ua tus nqa cov tshuaj noj, txhaj tshuaj, cov txheej txheem xa tshuaj mucosal (xws li cov mucosa ntawm lub qhov ntswg, qhov quav, lub qhov muag, thiab lwm yam), cov txheej txheem xa tshuaj transdermal nqus, cov tshuaj lipophilic targeted, thiab kuj tuaj yeem siv ua tus tiv thaiv protein thiab stabilizer.
Lub sijhawm tshaj tawm: Lub Kaum Hli-20-2023