Rau kev tu tawv nqaij zoo, ntawm chav kawm, nws yog ib qho tsim nyog yuav tsum muaj qee lub tswv yim ntawm cov khoom xyaw, tsis yog tsuas yog kev txhawb nqa ntawm cov khoom, tab sis kuj yog cov khoom xyaw ntawm cov khoom. Niaj hnub no, cia peb tham txog "carnosine" ntawm cov khoom xyaw ntawm cov khoom tu tawv nqaij.
Dab tsi yog 'Carnosine'
Carnosine yog ib qho dipeptide tsim los ntawm beta-alanine thiab L-histidine, uas muaj cov ntsiab lus siab hauv cov leeg thiab lub hlwb blocks. Carnosine muaj cov tshuaj antioxidant siab thiab tuaj yeem tshem tawm cov dawb radicals hauv lub cev.
Yuav ua li cas 'carnosine' ua haujlwm
Carnosine tuaj yeem ua rau cov tawv nqaij ua kom tsis muaj zog, tswj lub cev hluas ntawm cov hlwb los ntawm kev tswj xyuas cov haujlwm ntawm cov hlwb hauv tag nrho cov spectrum band thiab dawb radical mob, txhawb kev tsim cov collagen, thiab ua kom tawv nqaij elastic.
Lub luag haujlwm ntawm 'carnosine'
Carnosine tuaj yeem ua rau cov tawv nqaij ua kom tsis muaj zog, tswj lub cev hluas ntawm cov hlwb los ntawm kev tswj xyuas cov haujlwm ntawm cov hlwb hauv tag nrho cov spectrum band thiab dawb radical mob, txhawb kev tsim cov collagen, thiab ua kom tawv nqaij elastic. Cov tshuaj lom neeg ntawmL-carnosineyog tsim ntawm beta-alanine thiab L-histidine los ntawm kev ua ntawm carnosine synthase. Carnosine muaj cov ntawv thov dav dav hauv cov tshuaj, kev kho mob, thiab kev tu cev vim nws cov khoom antioxidant, dawb radical scavenging cuam tshuam, chelation nrog kev hloov pauv hlau, neuroprotection, kho qhov txhab txhawb, thiab tiv thaiv kev laus.
1. Kev siv cov carnosine hauv kev lag luam zaub mov
Lub ntsiab tseem ceeb ntawm cov roj hauv cov zaub mov yog sib xyaw ntawm ntau yam fatty acid glycerides. Vim yog cov tshuaj tiv thaiv dawb radical ntawm unsaturated fatty acid glycerides thaum lub sij hawm cia, peroxides thiab ntxhiab aldehydes los yog carboxylic acids nrog luv carbon chains yog generated. Yog li ntawd, noj cov zaub mov uas muaj roj peroxides yuav ntxiv lipid peroxidation nyob rau hauv tib neeg lub cev thiab induce ntau yam kab mob. Yog li ntawd, butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, thiab lwm yam yog feem ntau siv rau hauv kev ua zaub mov thiab cia kom tsis txhob muaj roj peroxidation, tab sis lawv cov kev ua tau zoo yuav txo qis hauv cov txheej txheem cua sov ntawm kev ua zaub mov, thiab nws muaj qee yam toxicity. L-carnosine tuaj yeem tsis tsuas yog cuam tshuam cov roj oxidation, tab sis kuj muaj kev nyab xeeb thiab kev saib xyuas kev noj qab haus huv. Yog li, L-carnosine yog ib qho khoom noj muaj txiaj ntsig thiab zoo tshaj plaws antioxidant.
2. Kev siv cov carnosine hauv tshuaj thiab kev kho mob
(1) Carnosine thiab Antioxidant
Carnosine tuaj yeem tsis tsuas yog siv lub nplhaib imidazole N atom thiab peptide daim ntawv cog lus N atom ntawm histidine residues rau chelate hlau ions thiab inhibit cov roj oxidation los ntawm cov hlau ions, tab sis kuj cov histidine nyob rau sab saw ntawm carnosine muaj peev xwm ntes hydroxyl radicals. Nws tuaj yeem cuam tshuam cov oxidation ntawm cov rog los ntawm cov hlau tsis yog hlau. Yog li ntawd, raws li ib tug multifunctional antioxidant active tshuaj, carnosine yuav stably tiv thaiv cell membrane thiab yog ib tug dej-soluble dawb radical scavenger. , tuaj yeem tiv thaiv peroxidation ntawm cell membrane. Piv nrog rau lwm cov tshuaj lom neeg antioxidants xws li VC, carnosine muaj zog antioxidant muaj peev xwm. Ntxiv nrog rau inhibiting cov txheej txheem peroxidation ntawm cov cell membrane, carnosine tuaj yeem cuam tshuam lwm cov tshuaj tiv thaiv kab mob hauv lub cev, uas yog, carnosine tuaj yeem cuam tshuam txhua kauj ruam ntawm cov tshuaj tiv thaiv oxidation nyob rau hauv tag nrho cov peroxidation saw nyob rau hauv lub cev. Lub luag haujlwm ntawm cov tshuaj antioxidants xws li VC yog los tiv thaiv cov dawb radicals los ntawm kev nkag mus rau hauv cov ntaub so ntswg, uas yog, lawv tsuas tuaj yeem tiv thaiv cov kua peroxidation txheej txheem ntawm cov cell membrane, thiab tsis tuaj yeem ua dab tsi rau cov dawb radicals uas tau nkag mus rau hauv lub cell.
(2) Carnosine thiab gastric ulcer
Peptic ulcer yog ib tug kab mob nyob rau hauv lub ntiaj teb no mob digestive system, thiab tej yam tseem ceeb uas ua rau ulcers tsis meej heev nyob rau hauv tam sim no, tab sis pathology ntseeg hais tias aggressive yam tseem ceeb (xws li gastric acid, pepsin secretion, Helicobacter pylori kab mob) thiab tiv thaiv los yog cellular tshwm sim los ntawm ib tug kab mob. kev tsis sib haum xeeb ntawm cov khoom tiv thaiv (cov qog ua kua ua kua, bicarbonate secretion, prostaglandin ntau lawm). Lub ntuj tiv thaiv mechanism ntawm lub plab yog: nws tsim ib tug tuab txheej ntawm gastric mucosa uas ua hauj lwm raws li ib tug tiv thaiv barrier los tiv thaiv lub hlwb nyob rau hauv ob sab phlu. Kev tso tawm tsis tu ncua ntawm cov mucous membrane tiv thaiv lub plab, tab sis kev tso tawm ntau dhau tuaj yeem ua rau mob plab. Cov kev tshawb fawb tau pom tias zinc-carnosine noj nrog cov zaub mov tuaj yeem tiv thaiv cov kab mob zoo, nws tuaj yeem tswj kev ncaj ncees ntawm lub plab thiab nws cov txheej txheem tiv thaiv ntuj, qhov no yog vim carnosine cov khoom antioxidant, daim nyias nyias stabilization, kev tswj cov tshuaj pharmacological ntawm kev tiv thaiv kab mob thiab kho cov ntaub so ntswg. Raws li kev sim tshuaj, tom qab noj zinc-carnosine rau yim lub lis piam, 70% ntawm cov neeg mob uas tau siv cov tshuaj pom tau tias muaj kev txhim kho tseem ceeb, thiab 65% ntawm cov kab mob plab tau txhim kho los ntawm kev siv tshuaj gastroscopy.
(3) Carnosine thiab kev tiv thaiv kab mob
Kev tiv thaiv kab mob yog ib qho kev ua haujlwm ntawm lub cev uas tswj hwm homeostasis thiab tswj hwm los ntawm cov khoom siv physiologically hauv cov kab mob nyob. Immunomodulators xa mus rau kev kho mob ntawm ib chav kawm ntawm cov kab mob tshwm sim los ntawm kev tiv thaiv kab mob, thiab siv los kho cov kab mob tiv thaiv kab mob, inhibit nws qhov kev poob qis lossis txo qis nws cov lus teb sai. Feem ntau ntawm cov immunomodulators uas twb muaj lawm yog synthesized los ntawm cov tshuaj synthesis txoj kev, uas muaj tej yam tshuaj lom thiab phiv. Cov kev tshawb fawb tau pom tias carnosine muaj kev ua haujlwm ntawm immunomodulatory, thiab nws yog tib lub cev muaj zog uas muaj nyob rau tam sim no rau immunomodulation, thiab nws tau siv dav hauv kev kho mob ntawm ntau yam kab mob thiab kab mob uas tshwm sim los ntawm kev tiv thaiv tsis zoo.
Post lub sij hawm: Sep-14-2022