Rau kev saib xyuas daim tawv nqaij zoo, tau kawg, nws yog qhov tsis zam kom muaj lub tswv yim ntawm cov khoom xyaw, tsis yog tsuas yog kev txhawb nqa cov khoom xwb, tab sis kuj yog cov khoom xyaw ntawm cov khoom. Hnub no, cia peb tham txog "carnosine" ntawm cov khoom xyaw ntawm cov khoom saib xyuas daim tawv nqaij.
'Carnosine' yog dab tsi?
Carnosine yog ib qho dipeptide uas muaj beta-alanine thiab L-histidine, uas muaj ntau nyob rau hauv cov leeg thiab cov hlwb blocks. Carnosine muaj cov khoom antioxidant siab thiab tuaj yeem scavenge cov free radicals hauv lub cev.
Yuav ua li cas 'carnosine' ua haujlwm
Carnosine tuaj yeem ua rau daim tawv nqaij tiv taus ntau dua, tswj cov hlwb kom hluas dua los ntawm kev tswj cov haujlwm ntawm cov hlwb hauv cov kab spectrum tag nrho thiab cov xwm txheej dawb radical, txhawb kev tsim cov collagen, thiab ua kom daim tawv nqaij ywj pheej.
Lub luag haujlwm ntawm 'carnosine'
Carnosine tuaj yeem ua rau daim tawv nqaij tiv taus ntau dua, tswj cov hlwb kom hluas dua los ntawm kev tswj cov haujlwm ntawm cov hlwb hauv cov kab spectrum tag nrho thiab cov xwm txheej dawb radical, txhawb kev tsim cov collagen, thiab ua kom daim tawv nqaij ywj pheej. Lub xwm txheej tshuaj ntawmL-carnosineyog kev tsim cov beta-alanine thiab L-histidine los ntawm kev ua haujlwm ntawm carnosine synthase. Carnosine muaj kev siv dav hauv kev kho mob, kev kho mob, thiab kev tu cev vim nws cov khoom antioxidant, cov teebmeem scavenging dawb, chelation nrog cov hlau hloov pauv, neuroprotection, kev txhawb nqa kev kho qhov txhab, thiab tiv thaiv kev laus.
1. Daim ntawv thov ntawm carnosine hauv kev lag luam zaub mov
Cov khoom tseem ceeb ntawm cov roj hauv cov zaub mov yog sib xyaw ntawm ntau yam fatty acid glycerides. Vim yog cov tshuaj tiv thaiv dawb ntawm cov unsaturated fatty acid glycerides thaum lub sijhawm khaws cia, peroxides thiab aldehydes tsw qab lossis carboxylic acids nrog cov saw hlau luv luv raug tsim. Yog li ntawd, kev noj cov zaub mov uas muaj cov roj peroxides yuav txhawb nqa lipid peroxidation hauv tib neeg lub cev thiab ua rau muaj ntau yam kab mob. Yog li ntawd, butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, thiab lwm yam feem ntau siv rau hauv kev ua zaub mov thiab khaws cia kom tiv thaiv cov rog peroxidation, tab sis lawv cov txiaj ntsig yuav raug txo qis hauv cov txheej txheem cua sov ntawm kev ua zaub mov, thiab nws muaj qee yam tshuaj lom. L-carnosine tsis tsuas yog tuaj yeem tiv thaiv cov rog oxidation zoo, tab sis kuj muaj kev nyab xeeb siab thiab kev saib xyuas kev noj qab haus huv. Yog li ntawd, L-carnosine yog cov khoom noj khoom haus antioxidant muaj txiaj ntsig thiab zoo tagnrho.
2. Kev siv carnosine hauv kev kho mob thiab kev kho mob
(1) Carnosine thiab Antioxidant
Carnosine tsis yog tsuas yog siv lub nplhaib imidazole N atom thiab peptide bond N atom ntawm histidine residues los chelate hlau ions thiab inhibit cov rog oxidation los ntawm cov hlau ions, tab sis kuj histidine ntawm sab saw ntawm carnosine muaj peev xwm ntes hydroxyl radicals. Nws tuaj yeem inhibit qhov oxidation ntawm cov rog los ntawm cov tsis yog hlau ions. Yog li ntawd, ua ib qho tshuaj antioxidant ntau yam, carnosine tuaj yeem tiv thaiv lub cell membrane thiab yog cov dej-soluble free radical scavenger. , tuaj yeem tiv thaiv peroxidation ntawm lub cell membrane. Piv nrog rau lwm cov tshuaj antioxidants biological xws li VC, carnosine muaj zog antioxidant peev xwm. Ntxiv nrog rau kev txwv tsis pub cov txheej txheem peroxidation ntawm lub cell membrane, carnosine kuj tseem tuaj yeem txwv tsis pub ntau lwm yam intracellular peroxidation reactions, uas yog, carnosine tuaj yeem txwv tsis pub txhua kauj ruam ntawm oxidation reaction hauv tag nrho peroxidation saw hauv lub cev. Lub luag haujlwm ntawm cov tshuaj antioxidants xws li VC yog los tiv thaiv cov free radicals los ntawm kev nkag mus rau hauv cov ntaub so ntswg, uas yog, lawv tsuas yog tuaj yeem tiv thaiv cov txheej txheem kua peroxidation ntawm lub cell membrane, thiab tsis tuaj yeem ua dab tsi rau cov free radicals uas tau nkag mus rau hauv lub cell.
(2) Carnosine thiab mob plab hnyuv
Kab mob plab yog ib yam kab mob thoob ntiaj teb uas ua rau lub plab zom mov tsis zoo, thiab cov yam ntxwv tshwj xeeb uas ua rau mob plab tsis meej tam sim no, tab sis kev tshawb fawb ntseeg tias cov yam ntxwv ua rau mob plab (xws li kua qaub hauv plab, kua qaub pepsin, kab mob Helicobacter pylori) thiab kev tiv thaiv lossis kev tiv thaiv ntawm tes yog los ntawm kev tsis sib npaug ntawm cov yam ntxwv tiv thaiv (kev tso zis ntawm cov hnoos qeev, kev tso zis ntawm bicarbonate, kev tsim cov prostaglandin). Lub tshuab tiv thaiv ntuj ntawm lub plab yog: nws tsim ib txheej tuab ntawm cov hnyuv plab uas ua haujlwm ua lub luag haujlwm tiv thaiv cov hlwb hauv daim ntaub. Kev tso zis tas mus li ntawm cov hnyuv plab tiv thaiv lub plab, tab sis kev tso zis ntau dhau tuaj yeem ua rau mob plab. Kev tshawb fawb tau pom tias zinc-carnosine noj nrog zaub mov tuaj yeem tiv thaiv cov mob plab tau zoo, nws tuaj yeem tswj tau qhov kev ncaj ncees ntawm lub plab thiab nws lub tshuab tiv thaiv ntuj, qhov no yog vim carnosine cov khoom antioxidant, kev ruaj khov ntawm daim nyias nyias, kev tswj hwm cov khoom siv tshuaj ntawm kev tiv thaiv kab mob thiab kho cov ntaub so ntswg. Raws li kev sim tshuaj, tom qab noj zinc-carnosine rau yim lub lis piam, 70% ntawm cov neeg mob uas tau noj cov tshuaj tau pom tias muaj kev txhim kho zoo, thiab 65% ntawm cov mob plab tau zoo dua los ntawm gastroscopy.
(3) Carnosine thiab kev tswj hwm kev tiv thaiv kab mob
Kev tiv thaiv kab mob yog ib qho kev ua haujlwm ntawm lub cev uas tswj tau homeostasis thiab raug tswj los ntawm cov tshuaj ua haujlwm hauv lub cev. Cov tshuaj immunomodulators hais txog kev kho mob ntawm ib pawg kab mob uas tshwm sim los ntawm kev ua haujlwm tsis zoo ntawm lub cev, thiab siv los kho qhov kev tiv thaiv kab mob, tiv thaiv nws qhov kev poob qis tsis zoo lossis tiv thaiv nws qhov kev teb sai. Feem ntau ntawm cov tshuaj immunomodulators uas twb muaj lawm yog tsim los ntawm cov txheej txheem tshuaj lom neeg, uas muaj qee yam tshuaj lom thiab cov teebmeem sab nraud. Cov kev tshawb fawb tau qhia tias carnosine muaj kev ua haujlwm immunomodulatory, thiab nws yog tib yam tshuaj ua haujlwm ntawm lub cev uas pom txog tam sim no rau kev tiv thaiv kab mob, thiab nws tau siv dav hauv kev kho mob ntawm ntau yam kab mob tiv thaiv kab mob thiab cov kab mob uas tshwm sim los ntawm kev tiv thaiv kab mob tsis zoo.
Lub sijhawm tshaj tawm: Cuaj hlis-14-2022